Efficacy and Safety of Ciprofol Sedation in ICU Patients Undergoing Mechanical Ventilation: A Multicenter, Single-Blind, Randomized, Noninferiority Trial.

ABSTRACT:

Objectives

To determine the effectiveness and safety of ciprofol for sedating patients in ICUs who required mechanical ventilation (MV).

Design

A multicenter, single-blind, randomized, noninferiority trial.

Setting

Twenty-one centers across China from December 2020 to June 2021.

Patients

A total of 135 ICU patients 18 to 80 years old with endotracheal intubation and undergoing MV, who were expected to require sedation for 6-24 hours.

Interventions

One hundred thirty-five ICU patients were randomly allocated into ciprofol ( n = 90) and propofol ( n = 45) groups in a 2:1 ratio. Ciprofol or propofol were IV infused at loading doses of 0.1 mg/kg or 0.5 mg/kg, respectively, over 4 minutes ± 30 seconds depending on the physical condition of each patient. Cipro

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10497206 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature