Alk1 acts in non-endothelial VE-cadherin⁺ perineurial cells to maintain nerve branching during hair homeostasis.

ABSTRACT: Vascular endothelial (VE)-cadherin is a well-recognized endothelial cell marker. One of its interacting partners, the TGF-β receptor Alk1, is essential in endothelial cells for adult skin vasculature remodeling during hair homeostasis. Using single-cell transcriptomics, lineage tracing and gene targeting in mice, we characterize the cellular and molecular dynamics of skin VE-cadherin⁺ cells during hair homeostasis. We describe dynamic changes of VE-cadherin⁺ endothelial cells specific to blood and lymphatic vessels and uncover an atypical VE-cadherin⁺ cell population. The latter is not a predicted adult endovascular progenitor, but rather a non-endothelial mesenchymal perineurial cell type, which forms nerve encapsulating tubular structures that undergo rem

SUBMITTER: Chovatiya G 

PROVIDER: S-EPMC10497554 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature