Burden of untreated transthyretin amyloid cardiomyopathy on patients and their caregivers by disease severity: results from a multicenter, non-interventional, real-world study.

ABSTRACT:

Background

The humanistic burden of transthyretin amyloid cardiomyopathy (ATTR-CM) is poorly defined.

Methods

An international study to comprehensively characterize the burden of ATTR-CM on patients naïve to disease-modifying therapy and their unpaid primary caregivers using study-specific and established surveys (patients: Kansas City Cardiomyopathy Questionnaire Overall Summary [KCCQ-OS], 12-Item Short Form Health Survey [SF-12], Hospital Anxiety and Depression Scale [HADS], Patient-Reported Outcomes Measurement Information System [PROMIS] Fatigue and Dyspnea; caregivers: SF-12, HADS, PROMIS Fatigue, Zarit Burden Interview [ZBI]). All data were summarized descriptively.

Results

208 patient and caregiver pairs were included. 86% of patients were male, median age was

SUBMITTER: Ponti L 

PROVIDER: S-EPMC10497948 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature