SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile.

ABSTRACT:

Background

The immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in COVID-19 patients has been extensively investigated. However, much less is known about the long-term effects of infection in patients and how it could affect the immune system and its capacity to respond to future perturbations.

Methods

Using a targeted single-cell multiomics approach, we have recently identified a prolonged anti-inflammatory gene expression signature in T and NK cells in type 1 diabetes patients treated with low-dose IL-2. Here, we investigated the dynamics of this signature in three independent cohorts of COVID-19 patients: (i) the Oxford COVID-19 Multi-omics Blood Atlas (COMBAT) dataset, a cross-sectional cohort including 77 COVID-19 patients and te

SUBMITTER: Zhang JY 

PROVIDER: S-EPMC10498514 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature