Effect of anatomical liver resection for hepatocellular carcinoma: a systematic review and meta-analysis.

ABSTRACT:

Background

Despite retrospective studies comparing anatomical liver resection (AR) and nonanatomical liver resection (NAR), the efficacy and benefits of AR for hepatocellular carcinoma (HCC) remain unclear.

Materials and methods

We systemically reviewed MEDLINE, Embase, and Cochrane Library for propensity score matched (PSM) cohort studies that compared AR and NAR for HCC. Primary outcomes were overall survival (OS) and recurrence-free survival (RFS). Secondary outcomes were recurrence patterns and perioperative outcomes.

Results

Overall, 22 PSM studies (AR, n=2,496; NAR, n=2,590) were included. AR including systemic segmentectomy was superior to NAR regarding the 3- and 5-year OS. AR showed significantly better 1-, 3-, and 5-year RFS than NAR, with low local and mult

SUBMITTER: Shin SW 

PROVIDER: S-EPMC10498869 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature