Genomic alterations of oligodendrogliomas at distant recurrence.

ABSTRACT:

Background

Oligodendroglioma is known for its relatively better prognosis and responsiveness to radiotherapy and chemotherapy. However, little is known about the evolution of genetic changes as oligodendroglioma progresses.

Methods

In this study, we evaluated gene evolution invivo during tumor progression based on deep whole-genome sequencing data (ctDNA). We analyzed longitudinal genomic data from six patients during tumor evolution, of which five patients developed distant recurrence.

Results

Whole-exome sequencing demonstrated that the rate of shared mutations between the primary and recurrent samples was relatively low. In two cases, even well-known major driver mutations in CIC and FUBP1 that were detected in primary tumors were not detected in the relapse sample

SUBMITTER: Liu G 

PROVIDER: S-EPMC10501240 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature