Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC10502058 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Zhang Shirong S He Shutao S Zhu Xin X Wang Yunfei Y Xie Qionghuan Q Song Xianrang X Xu Chunwei C Wang Wenxian W Xing Ligang L Xia Chengqing C Wang Qian Q Li Wenfeng W Zhang Xiaochen X Yu Jinming J Ma Shenglin S Shi Jiantao J Gu Hongcang H
Nature communications 20230914 1
Identifying the primary site of metastatic cancer is critical to guiding the subsequent treatment. Approximately 3-9% of metastatic patients are diagnosed with cancer of unknown primary sites (CUP) even after a comprehensive diagnostic workup. However, a widely accepted molecular test is still not available. Here, we report a method that applies formalin-fixed, paraffin-embedded tissues to construct reduced representation bisulfite sequencing libraries (FFPE-RRBS). We then generate and systemati ...[more]