Effects of polymer terminal group inside micelle core on paclitaxel loading promoting and burst release suppressing.

ABSTRACT:

Background

Paclitaxel (PTX) is widely used in the treatment of advanced esophageal and gastric cancer. Polymeric micelles can improve the drug-loading efficiency of PTX. However, the end groups on the amphiphilic blocks affect the drug-loading efficiency and the release kinetics of polymeric micelles. Therefore, there is an urgent need to disclose the tailoring of the core-/shell-forming terminal groups.

Methods

Different from the conventional block copolymer synthesis in the reversible addition-fragmentation chain-transfer polymerization, which has a hydrophilic end group on the core-forming blocks, an alternative monomer addition method was applied to tune and obtain two block copolymers with symmetrical and similar block length PBMA_n-b-PNAM_m [

SUBMITTER: He H 

PROVIDER: S-EPMC10502554 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature