CircRHOT1 restricts gastric cancer cell ferroptosis by epigenetically regulating GPX4.

ABSTRACT:

Background

Gastric cancer (GC) is a malignant form of cancer that severely threatens human health. Despite developments on treatment, the prognosis of patients with advanced GC remains poor. Hence, the identification of detailed molecular mechanisms and potential therapeutic targets is of great importance for GC study. In recent years, circular RNAs have been widely reported to be important regulators in cancer initiation and progression. This study sought to evaluate the function of circRHOT1 in GC development.

Methods

Clinical specimens were collected from patients with GC to detect the level of circRHOT1. The expression of circRHOT1 in several GC cell lines was detected by quantitative real-time polymerase chain reaction. Cell Counting Kit 8 (CCK-8), colony formation, and

SUBMITTER: Wang H 

PROVIDER: S-EPMC10502555 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature