Dataset Information

Circulating microRNAs can predict chemotherapy-induced toxicities in patients being treated for primary breast cancer.

ABSTRACT:

Purpose

Prescribing NAC for breast cancer is a pragmatic treatment strategy for several reasons; however, certain patients suffer chemotherapy-induced toxicities. Unfortunately, identifying patients at risk of toxicity often proves challenging. MiRNAs are small non-coding RNA molecules which modulate genetic expression. The aim of this study was to determine whether circulating miRNAs are sensitive biomarkers that can identify the patients likely to suffer treatment-related toxicities to neoadjuvant chemotherapy (NAC) for primary breast cancer.

Methods

This secondary exploratory from the prospective, multicentre translational research trial (CTRIAL ICORG10/11-NCT01722851) recruited 101 patients treated with NAC for breast cancer, from eight treatment sites across Ireland. A predetermined five miRNAs panel was quantified using RQ-PCR from patient bloods at diagnosis. MiRNA expression was correlated with chemotherapy-induced toxicities. Regression analyses was performed using SPSS v26.0.

Results

One hundred and one patients with median age of 55 years were recruited (range: 25-76). The mean tumour size was 36 mm and 60.4% had nodal involvement (n = 61) Overall, 33.7% of patients developed peripheral neuropathies (n = 34), 28.7% developed neutropenia (n = 29), and 5.9% developed anaemia (n = 6). Reduced miR-195 predicted patients likely to develop neutropenia (P = 0.048), while increased miR-10b predicted those likely to develop anaemia (P = 0.049). Increased miR-145 predicted those experiencing nausea and vomiting (P = 0.019), while decreased miR-21 predicted the development of mucositis (P = 0.008).

Conclusion

This is the first study which illustrates the value of measuring circulatory miRNA to predict patient-specific toxicities to NAC. These results support the ideology that circulatory miRNAs are biomarkers with utility in predicting chemotherapy toxicity as well as treatment response.

SUBMITTER: Davey MG

PROVIDER: S-EPMC10504160 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

Circulating microRNAs can predict chemotherapy-induced toxicities in patients being treated for primary breast cancer.

Davey Matthew G MG Abbas Ray R Kerin Eoin P EP Casey Maire Caitlin MC McGuire Andrew A Waldron Ronan M RM Heneghan Helen M HM Newell John J McDermott Ailbhe M AM Keane Maccon M MM Lowery Aoife J AJ Miller Nicola N Kerin Michael J MJ

Breast cancer research and treatment 20230804 1

<h4>Purpose</h4>Prescribing NAC for breast cancer is a pragmatic treatment strategy for several reasons; however, certain patients suffer chemotherapy-induced toxicities. Unfortunately, identifying patients at risk of toxicity often proves challenging. MiRNAs are small non-coding RNA molecules which modulate genetic expression. The aim of this study was to determine whether circulating miRNAs are sensitive biomarkers that can identify the patients likely to suffer treatment-related toxicities to ...[more]

PMID: 37540289

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Dataset Information

Circulating microRNAs can predict chemotherapy-induced toxicities in patients being treated for primary breast cancer.

Purpose

Methods

Results

Conclusion

Publications

Circulating microRNAs can predict chemotherapy-induced toxicities in patients being treated for primary breast cancer.

Similar Datasets

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