Molecular docking analysis of calcium channel blockers with ALR2 and RAGE.
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ABSTRACT:
SUBMITTER: Kazmi S
PROVIDER: S-EPMC10504517 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
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Molecular docking analysis of calcium channel blockers with ALR2 and RAGE.
Kazmi Samreen S Challa Surekha S Alaparthi Malini Devi MD M Indira Devi ID Nagamalla Swetha Sudha SS Ej Priya P
Bioinformation 20230131 1
A metabolic condition called diabetes mellitus is linked to a number of substantial challenges. Advanced Glycation End Products (AGEs) and Aldose reductase (ALR2) are crucial in the slow development of several secondary complications. Selected calcium channel blockers (CCB's-1, 4-dihydropyridines) were docked against ALR2 (PDB code: 1Z3N) and RAGE (PDB code: 3CJJ) in the current study. We report that 1, 4-dihydropyridine compounds, particularly Benidipine, bind to the active sites with good effi ...[more]
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