A3DyDB: exploring structural aggregation propensities in the yeast proteome.

ABSTRACT:

Background

The budding yeast Saccharomyces cerevisiae (S. cerevisiae) is a well-established model system for studying protein aggregation due to the conservation of essential cellular structures and pathways found across eukaryotes. However, limited structural knowledge of its proteome has prevented a deeper understanding of yeast functionalities, interactions, and aggregation.

Results

In this study, we introduce the A3D yeast database (A3DyDB), which offers an extensive catalog of aggregation propensity predictions for the S. cerevisiae proteome. We used Aggrescan 3D (A3D) and the newly released protein models from AlphaFold2 (AF2) to compute the structure-based aggregation predictions for 6039 yeast proteins. The A3D algorithm exploits the information from 3D protein struc

SUBMITTER: Garcia-Pardo J 

PROVIDER: S-EPMC10504709 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature