Maternal health and pregnancy outcomes in autosomal dominant tubulointerstitial kidney disease.

ABSTRACT:

Introduction

Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an increasingly recognized cause of chronic kidney disease. ADTKD pregnancy outcomes have not previously been described.

Methods

A cross-sectional survey was sent to women from ADTKD families.

Results

Information was obtained from 85 afffected women (164 term pregnancies) and 23 controls (50 pregnancies). Only 16.5% of genetically affected women knew they had ADTKD during pregnancy. Eighteen percent of ADTKD mothers had hypertension during pregnancy versus 12% in controls (p  =  0.54) and >40% in comparative studies of chronic kidney disease in pregnancy. Eleven percent of births of ADTKD mothers were <37 weeks versus 0 in controls (p < 0.0001). Cesarean section occurred in 19%

SUBMITTER: Bleyer AJ 

PROVIDER: S-EPMC10504889 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature