NAD⁺ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension.

ABSTRACT: Hypertension is characterized by endothelial dysfunction and arterial stiffness, which contribute to the pathogenesis of atherosclerotic cardiovascular diseases. Nicotinamide adenine dinucleotide (NAD⁺) is an indispensable cofactor in all living cells that is involved in fundamental biological processes. However, in hypertensive patients, alterations in NAD⁺ levels and their relation with blood pressure (BP) elevation and vascular damage have not yet been studied. Here we reported that hypertensive patients exhibited lower NAD⁺ levels, as detected by high-performance liquid chromatography-mass spectrometry (HPLC-MS), in both peripheral blood mononuclear cells (PBMCs) and aortas, which was parallel to vascular dysfunction. NAD⁺ boosting therapy wi

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC10505611 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature