Serum uric acid and prognosis in acute ischemic stroke: a dose-response meta-analysis of cohort studies.

ABSTRACT:

Background

There have been contradictory findings regarding the relationship between serum uric acid levels and prognosis in acute ischemic stroke. Whether this association is nonlinear due to uric acid's paradoxical properties (antioxidant and prooxidant) is unclear.

Methods

We searched PubMed, Web of Science, and Embase databases until December 2022. Cohort studies reporting serum uric acid levels and functional outcome, mortality, or neurological complications in patients with acute ischemic stroke were included. Summary effect estimates were calculated using a random-effect model. Moreover, dose-response relationships were assessed by the generalized least squares trend estimation.

Results

Altogether, 13 cohort studies were identified in this study. Compared to th

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10505709 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature