Deviant spontaneous neural activity as a potential early-response predictor for therapeutic interventions in patients with schizophrenia.

ABSTRACT:

Objective

Previous studies have established significant differences in the neuroimaging characteristics between healthy controls (HCs) and patients with schizophrenia (SCZ). However, the relationship between homotopic connectivity and clinical features in patients with SCZ is not yet fully understood. Furthermore, there are currently no established neuroimaging biomarkers available for the diagnosis of SCZ or for predicting early treatment response. The aim of this study is to investigate the association between regional homogeneity and specific clinical features in SCZ patients.

Methods

We conducted a longitudinal investigation involving 56 patients with SCZ and 51 HCs. The SCZ patients underwent a 3-month antipsychotic treatment. Resting-state functional magnetic resonance

SUBMITTER: Jing H 

PROVIDER: S-EPMC10505796 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature