Dataset Information

The SunBEAm birth cohort: Protocol design.

ABSTRACT:

Background

Food allergy (FA) and atopic dermatitis (AD) are common conditions that often present in the first year of life. Identification of underlying mechanisms and environmental determinants of FA and AD is essential to develop and implement effective prevention and treatment strategies. Objectives: We sought to describe the design of the Systems Biology of Early Atopy (SunBEAm) birth cohort.

Methods

Funded by the National Institute of Allergy and Infectious Diseases (NIAID) and administered through the Consortium for Food Allergy Research (CoFAR), SunBEAm is a US population-based, multicenter birth cohort that enrolls pregnant mothers, fathers, and their newborns and follows them to 3 years. Questionnaire and biosampling strategies were developed to apply a systems biology approach to identify environmental, immunologic, and multiomic determinants of AD, FA, and other allergic outcomes.

Results

Enrollment is currently underway. On the basis of an estimated FA prevalence of 6%, the enrollment goal is 2500 infants. AD is defined on the basis of questionnaire and assessment, and FA is defined by an algorithm combining history and testing. Although any FA will be recorded, we focus on the diagnosis of egg, milk, and peanut at 5 months, adding wheat, soy, cashew, hazelnut, walnut, codfish, shrimp, and sesame starting at 12 months. Sampling includes blood, hair, stool, dust, water, tape strips, skin swabs, nasal secretions, nasal swabs, saliva, urine, functional aspects of the skin, and maternal breast milk and vaginal swabs.

Conclusions

The SunBEAm birth cohort will provide a rich repository of data and specimens to interrogate mechanisms and determinants of early allergic outcomes, with an emphasis on FA, AD, and systems biology.

SUBMITTER: Keet C

PROVIDER: S-EPMC10509956 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Publications

The SunBEAm birth cohort: Protocol design.

Keet Corinne C Sicherer Scott H SH Bunyavanich Supinda S Visness Cynthia C Fulkerson Patricia C PC Togias Alkis A Davidson Wendy W Perry Susan S Hamrah Sanaz S Calatroni Agustin A Robinson Katina K Dunaway Lars L Davis Carla M CM Anvari Sara S Leong-Kee Susan M SM Hershey Gurjit Khurana GK DeFranco Emily E Devonshire Ashley A Kim Haejin H Joseph Christine C Davidson Brent B Strong Noel K NK Tsuang Angela J AJ Groetch Marion M Wang Julie J Dantzer Jennifer J Mudd Kim K Aina Abimbola A Shreffler Wayne W Yuan Qian Q Simmons Virginia V Leung Donald Y M DYM Hui-Beckman Jessica J Ramos Jania Arcia JA Chinthrajah Sharon S Winn Virginia V Sindher Tina T Jones Stacie M SM Manning Nirvana A NA Scurlock Amy M AM Kim Edwin E Stuebe Alison A Gern James E JE Singh Anne Marie AM Krupp Jennifer J Wood Robert A RA

The journal of allergy and clinical immunology. Global 20230603 3

<h4>Background</h4>Food allergy (FA) and atopic dermatitis (AD) are common conditions that often present in the first year of life. Identification of underlying mechanisms and environmental determinants of FA and AD is essential to develop and implement effective prevention and treatment strategies. Objectives: We sought to describe the design of the Systems Biology of Early Atopy (SunBEAm) birth cohort.<h4>Methods</h4>Funded by the National Institute of Allergy and Infectious Diseases (NIAID) a ...[more]

PMID: 37771674

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Dataset Information

The SunBEAm birth cohort: Protocol design.

Background

Methods

Results

Conclusions

Publications

The SunBEAm birth cohort: Protocol design.

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