Dataset Information

Is Height^2.7 Appropriate for Indexation of Left Ventricular Mass in Healthy Adolescents? The Importance of Sex Differences.

ABSTRACT:

Background

Left ventricular mass (LVM) is an important predictor of cardiovascular risk. In adolescence, LVM is commonly indexed to height^2.7, although some evidence suggests that this may not fully account for sex differences.

Methods

We investigated appropriate allometric scaling of LVM to height, total lean mass, and body surface area, in a UK birth cohort of 2039 healthy adolescents (17±1 years). Allometric relationships were determined by linear regression stratified by sex, following log transformation of x and y variables [log(y)=a+b×log(x)], b is the allometric exponent.

Results

Log (LVM) showed linear relationships with log(height) and log(lean mass). Biased estimates of slope resulted when the sexes were pooled. The exponents were lower than the conventional estimate of 2.7 for males (mean [95% CI]=1.66 [1.30-2.03]) and females (1.58 [1.27-1.90]). When LVM was indexed to lean mass, the exponent was 1.16 (1.05-1.26) for males and 1.07 (0.97-1.16) for females. When LVM was indexed to estimated body surface area, the exponent was 1.53 (1.40-1.66) for males and 1.34 (1.24-1.45) for females.

Conclusions

Allometric exponents derived from pooled data, including men and women without adjustment for sex were biased, possibly due to sex differences in body composition. We suggest that when assessing LVM, clinicians should consider body size, body composition, sex, and age. Our observations may also have implications for the identification of young individuals with cardiac hypertrophy.

SUBMITTER: Taylor HCM

PROVIDER: S-EPMC10510825 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Publications

Is Height<sup>2.7</sup> Appropriate for Indexation of Left Ventricular Mass in Healthy Adolescents? The Importance of Sex Differences.

Taylor Hannah C M HCM Chaturvedi Nishi N Davey Smith George G Ferreira Diana L S DLS Fraser Abigail A Howe Laura D LD Hughes Alun D AD Lawlor Debbie A DA Timpson Nic J NJ Park Chloe M CM

Hypertension (Dallas, Tex. : 1979) 20230807 10

<h4>Background</h4>Left ventricular mass (LVM) is an important predictor of cardiovascular risk. In adolescence, LVM is commonly indexed to height<sup>2.7</sup>, although some evidence suggests that this may not fully account for sex differences.<h4>Methods</h4>We investigated appropriate allometric scaling of LVM to height, total lean mass, and body surface area, in a UK birth cohort of 2039 healthy adolescents (17±1 years). Allometric relationships were determined by linear regression stratifi ...[more]

PMID: 37548044

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Dataset Information

Is Height^2.7 Appropriate for Indexation of Left Ventricular Mass in Healthy Adolescents? The Importance of Sex Differences.

Background

Methods

Results

Conclusions

Publications

Is Height<sup>2.7</sup> Appropriate for Indexation of Left Ventricular Mass in Healthy Adolescents? The Importance of Sex Differences.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Is Height2.7 Appropriate for Indexation of Left Ventricular Mass in Healthy Adolescents? The Importance of Sex Differences.

Background

Methods

Results

Conclusions

Publications

Is Height&lt;sup&gt;2.7&lt;/sup&gt; Appropriate for Indexation of Left Ventricular Mass in Healthy Adolescents? The Importance of Sex Differences.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Is Height^2.7 Appropriate for Indexation of Left Ventricular Mass in Healthy Adolescents? The Importance of Sex Differences.

Is Height<sup>2.7</sup> Appropriate for Indexation of Left Ventricular Mass in Healthy Adolescents? The Importance of Sex Differences.