Stress Biomarkers and Child Development in Young Children in Bangladesh.

ABSTRACT:

Background

Hundreds of millions of children in low- and middle-income countries are exposed to chronic stressors, such as poverty, poor sanitation and hygiene, and sub-optimal nutrition. These stressors can have physiological consequences for children and may ultimately have detrimental effects on child development. This study explores associations between biological measures of chronic stress in early life and developmental outcomes in a large cohort of young children living in rural Bangladesh.

Methods

We assessed physiologic measures of stress in the first two years of life using measures of the hypothalamic-pituitary-adrenal (HPA) axis (salivary cortisol and glucocorticoid receptor gene methylation), the sympathetic-adrenal-medullary (SAM) system (salivary alpha-amylase,

SUBMITTER: Butzin-Dozier Z 

PROVIDER: S-EPMC10516093 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature