Sulawesi propolis induces higher apoptotic activity and lower inflammatory activity in a rat endometriosis model.

ABSTRACT:

Background

Endometriosis has a major impact on women's quality of life. The two primary pathologies are chronic inflammation and altered apoptotic activity. Sulawesi propolis has been shown to have known anti-inflammatory and pro-apoptotic properties in other diseases.

Objective

To investigate the effects of Sulawesi propolis in the rat endometriosis model.

Methods

An autologous endometriosis model was created in 60 female Wistar rats by laparotomy. Rats were divided into four groups (n = 15 in each group): control group (CG), dienogest group (DG), propolis 50 mg/kg body weight (BW)/day (P50) group, and propolis 100 mg/kg BW/day (P100) group. Each treatment group was divided into three different treatment durations (n = 5 in each treatment group): 2, 4 a

SUBMITTER: Situmorang H 

PROVIDER: S-EPMC10518513 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature