Patient-specific models link neurotransmitter receptor mechanisms with motor and visuospatial axes of Parkinson's disease.
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ABSTRACT:
SUBMITTER: Khan AF
PROVIDER: S-EPMC10522603 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
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Patient-specific models link neurotransmitter receptor mechanisms with motor and visuospatial axes of Parkinson's disease.
Khan Ahmed Faraz AF Adewale Quadri Q Lin Sue-Jin SJ Baumeister Tobias R TR Zeighami Yashar Y Carbonell Felix F Palomero-Gallagher Nicola N Iturria-Medina Yasser Y
Nature communications 20230926 1
Parkinson's disease involves multiple neurotransmitter systems beyond the classical dopaminergic circuit, but their influence on structural and functional alterations is not well understood. Here, we use patient-specific causal brain modeling to identify latent neurotransmitter receptor-mediated mechanisms contributing to Parkinson's disease progression. Combining the spatial distribution of 15 receptors from post-mortem autoradiography with 6 neuroimaging-derived pathological factors, we detect ...[more]
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