Validation of a Multivariate Prediction Model of the Clinical Progression of Alzheimer's Disease in a Community-Dwelling Multiethnic Cohort.

ABSTRACT:

Background

The major aims of the three Predictors Studies have been to further our understanding of Alzheimer's disease (AD) progression sufficiently to predict the length of time from disease onset to major disease outcomes in individual patients with AD.

Objectives

To validate a longitudinal Grade of Membership (L-GoM) prediction algorithm developed using clinic-based, mainly white patients from the Predictors 2 Study in a statistically representative community-based sample of Hispanic (N = 211) and non-Hispanic (N = 62) older adults (with 60 males and 213 females) from the Predictors 3 Study and extend the algorithm to mild cognitive impairment (MCI).

Methods

The L-GoM model was applied to data collected at the initial Predictors 3 visit for 150 subjects with AD an

SUBMITTER: Stallard E 

PROVIDER: S-EPMC10528912 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature