Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Replacement: A Meta-analysis of Randomized Controlled Trials.

ABSTRACT:

Background

Stroke is a feared complication of transcatheter aortic valve replacement (TAVR), which embolic protection devices (EPDs) may mitigate. This systematic review and meta-analysis synthesized randomized controlled trials (RCTs) to evaluate the effect of EPDs in TAVR.

Methods

All RCTs comparing EPDs with control during TAVR were systematically identified. Prespecified primary end points were all stroke, disabling stroke, nondisabling stroke, and all-cause mortality. Safety and neuroimaging parameters were assessed. Sensitivity analyses were stratified by EPD type. Study registration was a priori (CRD42022377939).

Results

Eight trials randomizing 4043 patients were included. There was no significant difference between EPDs and control for all stroke (relative ri

SUBMITTER: Reddy RK 

PROVIDER: S-EPMC10533415 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature