Genetic and clinical variables act synergistically to impact neurodevelopmental outcomes in children with single ventricle heart disease.

ABSTRACT:

Background

Recent large-scale sequencing efforts have shed light on the genetic contribution to the etiology of congenital heart defects (CHD); however, the relative impact of genetics on clinical outcomes remains less understood. Outcomes analyses using genetics are complicated by the intrinsic severity of the CHD lesion and interactions with conditionally dependent clinical variables.

Methods

Bayesian Networks were applied to describe the intertwined relationships between clinical variables, demography, and genetics in a cohort of children with single ventricle CHD.

Results

As isolated variables, a damaging genetic variant in a gene related to abnormal heart morphology and prolonged ventilator support following stage I palliative surgery increase the probability of

SUBMITTER: Miller TA 

PROVIDER: S-EPMC10533527 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature