Understanding the relationship between circulating lipids and risk of chronic kidney disease: a prospective cohort study and large-scale genetic analyses.

ABSTRACT:

Background

This study aims to comprehensively investigate the phenotypic and genetic relationships between four common lipids (high-density lipoprotein cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; total cholesterol, TC; and triglycerides, TG), chronic kidney disease (CKD), and estimated glomerular filtration rate (eGFR).

Methods

We first investigated the observational association of lipids (exposures) with CKD (primary outcome) and eGFR (secondary outcome) using data from UK Biobank. We then explored the genetic relationship using summary statistics from the largest genome-wide association study of four lipids (N = 1,320,016), CKD (N_case = 41,395, N_control = 439,303), and eGFR(N = 567,460).

Results

There were significant phenot

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10537816 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature