Dataset Information

An enigma of hypothyroidism and hyponatremia coexistence: a nationwide population-based retrospective study.

ABSTRACT:

Introduction

Hypothyroidism is a rare and possible cause of hyponatremia. However, the clinical epidemiology and risk of mortality (ROM) when they coexist still remain elusive.

Objectives

We assessed the epidemiology and ROM among index patients with coexisting hypothyroidism and hyponatremia via a national population database.

Patients and methods

This retrospective cohort study utilized Taiwan's National Health Insurance program database. Distributions of definite sociodemographic factors were analyzed. The annual incidence among the overall group and sex-subgroups was investigated. In addition, potential factors influencing the ROM were also evaluated.

Results

Of 4,549,226 patients from 1998 to 2015, a total of 3,140 index patients with concurrent hypothyroidism and hyponatremia were analyzed. The incidence rate increased tenfold from 1998 to 2015; average annual incidence rate was 174. Among the total participants, 57.1% were women; mean age was 72.6 ± 14.7 years and 88.8% were aged > 55 years. Although average length of stay (LOS) was 13.1 ± 15.4 days, the mortality group had significantly longer LOS than that in the survival group (12.9 days vs 22.2 days). Old age, catastrophic illness, cardiac dysrhythmia, and low hospital hierarchy were independent predictors of hospital mortality. The optimal LOS cutoff value for ROM prediction was 16 days. Index patients with LOS > 16 days increased ROM by 2.3-fold.

Conclusions

Coexistent hypothyroidism and hyponatremia is rare, although the incidence increased gradually. Factors influencing the ROM, such as old age, underlying catastrophic status, cardiac dysrhythmia, hospital hierarchy, and LOS should be considered in clinical care.

SUBMITTER: Chu CH

PROVIDER: S-EPMC10541708 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Publications

An enigma of hypothyroidism and hyponatremia coexistence: a nationwide population-based retrospective study.

Chu Chun-Hao CH Chien Wu-Chien WC Liu Chiung-Chen CC Chung Chi-Hsiang CH Chen Ying-Chuan YC Kuo Feng-Chih FC Fang Hung-Hsiang HH Cheng Cheng-Yi CY Ding Yi-Xuan YX Tien Chiung-Hsi CH Lin Chien-Ming CM

BMC public health 20230929 1

<h4>Introduction</h4>Hypothyroidism is a rare and possible cause of hyponatremia. However, the clinical epidemiology and risk of mortality (ROM) when they coexist still remain elusive.<h4>Objectives</h4>We assessed the epidemiology and ROM among index patients with coexisting hypothyroidism and hyponatremia via a national population database.<h4>Patients and methods</h4>This retrospective cohort study utilized Taiwan's National Health Insurance program database. Distributions of definite sociode ...[more]

PMID: 37775735

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Dataset Information

An enigma of hypothyroidism and hyponatremia coexistence: a nationwide population-based retrospective study.

Introduction

Objectives

Patients and methods

Results

Conclusions

Publications

An enigma of hypothyroidism and hyponatremia coexistence: a nationwide population-based retrospective study.

Similar Datasets

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