Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation.

ABSTRACT: Memory consolidation involves discrete patterns of transcriptional events in the hippocampus. Despite the emergence of single-cell transcriptomic profiling techniques, mapping the transcriptomic signature across subregions of the hippocampus has remained challenging. Here, we utilized unbiased spatial sequencing to delineate transcriptome-wide gene expression changes across subregions of the dorsal hippocampus of male mice following learning. We find that each subregion of the hippocampus exhibits distinct yet overlapping transcriptomic signatures. The CA1 region exhibited increased expression of genes related to transcriptional regulation, while the DG showed upregulation of genes associated with protein folding. Importantly, our approach enabled us to define the transcriptomic signature

SUBMITTER: Vanrobaeys Y 

PROVIDER: S-EPMC10541893 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature