A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria.

ABSTRACT: The kidneys facilitate energy conservation through reabsorption of nutrients including glucose. Almost all of the filtered blood glucose is reabsorbed by the kidneys. Loss of glucose in urine (glycosuria) is offset by an increase in endogenous glucose production to maintain normal energy supply in the body. How the body senses this glucose loss and consequently enhances glucose production is unclear. Using renal Glut2 knockout mice, we demonstrate that elevated glycosuria activates the hypothalamic-pituitary-adrenal axis, which in turn drives endogenous glucose production. This phenotype was attenuated by selective afferent renal denervation, indicating the involvement of the afferent nerves in promoting the compensatory increase in glucose production. In addition, through plasma pr

SUBMITTER: Faniyan TS 

PROVIDER: S-EPMC10542134 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature