Ontology highlight
ABSTRACT:
SUBMITTER: Teng R
PROVIDER: S-EPMC3542973 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Nature communications 20111101
Although erythropoietin (Epo) is the cytokine known to regulate erythropoiesis, erythropoietin receptor (EpoR) expression and associated activity beyond haematopoietic tissue remain uncertain. Here we show that mice with EpoR expression restricted to haematopoietic tissues (Tg) develop obesity and insulin resistance. Tg-mice exhibit a decrease in energy expenditure and an increase in white fat mass and adipocyte number. Conversely, Epo treatment of wild-type (WT)-mice increases energy expenditur ...[more]