PET-measured human dopamine synthesis capacity and receptor availability predict trading rewards and time-costs during foraging.

ABSTRACT: Foraging behavior requires weighing costs of time to decide when to leave one reward patch to search for another. Computational and animal studies suggest that striatal dopamine is key to this process; however, the specific role of dopamine in foraging behavior in humans is not well characterized. We use positron emission tomography (PET) imaging to directly measure dopamine synthesis capacity and D₁ and D_2/3 receptor availability in 57 healthy adults who complete a computerized foraging task. Using voxelwise data and principal component analysis to identify patterns of variation across PET measures, we show that striatal D₁ and D_2/3 receptor availability and a pattern of mesolimbic and anterior cingulate cortex dopamine function are important fo

SUBMITTER: Ianni AM 

PROVIDER: S-EPMC10542376 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature