Loss of YTHDF2 Alters the Expression of m6A-Modified Myzap and Causes Adverse Cardiac Remodeling.
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ABSTRACT:
SUBMITTER: Golubeva VA
PROVIDER: S-EPMC10543918 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
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Loss of YTHDF2 Alters the Expression of m<sup>6</sup>A-Modified Myzap and Causes Adverse Cardiac Remodeling.
Golubeva Volha A VA Dorn Lisa E LE Gilbert Christopher J CJ Rabolli Charles P CP Das Anindhya Sundar AS Wanasinghe Vishmi S VS Veress Roland R Terentyev Dmitry D Accornero Federica F
JACC. Basic to translational science 20230621 9
How post-transcriptional regulation of gene expression, such as through <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) messenger RNA methylation, impacts heart function is not well understood. We found that loss of the m<sup>6</sup>A binding protein YTHDF2 in cardiomyocytes of adult mice drove cardiac dysfunction. By proteomics, we found myocardial zonula adherens protein (MYZAP) within the top up-regulated proteins in knockout cardiomyocytes. We further demonstrated that YTHDF2 binds m<s ...[more]
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