Macrophage migration inhibitory factor may contribute to the occurrence of multiple primary lung adenocarcinomas.

ABSTRACT:

Background

This study aimed to identify the key genes involved in the development of multiple primary lung cancers.

Methods

Differential expression analysis was performed, followed by comparing the infiltration levels of 22 immune cell types between multiple and single primary lung adenocarcinomas. Marker genes for epithelial cells with different proportions between the two types of lung adenocarcinomas were identified. The common genes between the marker genes and differentially expressed genes were identified. Finally, the effects of the key genes were tested on the in vitro proliferation, migration and morphology.

Results

The infiltration levels of helper follicular T cells, resting NK cells, activated NK cells, M2 macrophages and resting mast cells were higher in

SUBMITTER: Liu W 

PROVIDER: S-EPMC10545892 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature