Systems level identification of a matrisome-associated macrophage polarisation state in multi-organ fibrosis.

ABSTRACT: Tissue fibrosis affects multiple organs and involves a master-regulatory role of macrophages which respond to an initial inflammatory insult common in all forms of fibrosis. The recently unravelled multi-organ heterogeneity of macrophages in healthy and fibrotic human disease suggests that macrophages expressing osteopontin (SPP1) associate with lung and liver fibrosis. However, the conservation of this SPP1⁺ macrophage population across different tissues and its specificity to fibrotic diseases with different etiologies remain unclear. Integrating 15 single-cell RNA-sequencing datasets to profile 235,930 tissue macrophages from healthy and fibrotic heart, lung, liver, kidney, skin, and endometrium, we extended the association of SPP1⁺ macrophages with fibrosis to all

SUBMITTER: Ouyang JF 

PROVIDER: S-EPMC10547479 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature