The effect of increased positive end expiratory pressure on brain tissue oxygenation and intracranial pressure in acute brain injury patients.

ABSTRACT: Cerebral hypoxia is an important cause of secondary brain injury. Improving systemic oxygenation may increase brain tissue oxygenation (PbtO₂). The effects of increased positive end-expiratory pressure (PEEP) on PbtO₂ and intracranial pressure (ICP) needs to be further elucidated. This is a single center retrospective cohort study (2016-2021) conducted in a 34-bed Department of Intensive Care unit. All patients with acute brain injury under mechanical ventilation who were monitored with intracranial pressure and brain tissue oxygenation (PbtO₂) catheters and underwent at least one PEEP increment were included in the study. Primary outcome was the rate of PbtO₂ responders (increase in PbtO₂ > 20% of baseline) after PEEP increase. ΔPEEP

SUBMITTER: Gouvea Bogossian E 

PROVIDER: S-EPMC10547811 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature