Anticancer Potential of Diruthenium Complexes with Bridging Hydrocarbyl Ligands from Bioactive Alkynols.

ABSTRACT: Diruthenacyclopentenone complexes of the general composition [Ru₂Cp₂(CO)₂{μ-η¹:η³-CH═C(C(OH)(R))C(═O)}] (2a-c; Cp = η⁵-C₅H₅) were synthesized in 94-96% yields from the reactions of [Ru₂Cp₂(CO)₂{μ-η¹:η³-C(Ph)═C(Ph)C(═O)}] (1) with 1-ethynylcyclopentanol, 17α-ethynylestradiol, and 17-ethynyltestosterone, respectively, in toluene at reflux. Protonation of 2a-c by HBF₄ afforded the corresponding allenyl derivatives [Ru₂Cp₂(CO)₃{μ-η¹:η²-CH═C═R}]BF₄ (3a-c) in 85-93% yields. All products were thoroughly characterized by elemental an

SUBMITTER: Bresciani G 

PROVIDER: S-EPMC10548421 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature