Therapeutic Effect of Nicotinamide Mononucleotide for Hypoxic-Ischemic Brain Injury in Neonatal Mice.
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ABSTRACT: Summary statement
Neonatal hypoxia-ischemia reduces nicotinamide adenine dinucleotide (NAD+) and SIRT6 levels in the injured hippocampus.Hippocampal high mobility group box-1 (HMGB1) release is significantly increased after neonatal hypoxia-ischemia.Nicotinamide mononucleotide (NMN) treatment normalizes hippocampal NAD+ and SIRT6 levels, with significant decrease in caspase-3 activity and HMGB1 release.NMN improves early developmental behavior, as well as motor and memory function.
SUBMITTER: Kawamura T
PROVIDER: S-EPMC10548811 | biostudies-literature | 2023 Jan-Dec
REPOSITORIES: biostudies-literature
Publications
Therapeutic Effect of Nicotinamide Mononucleotide for Hypoxic-Ischemic Brain Injury in Neonatal Mice.
Kawamura Takuya T Singh Mallah Gagandeep G Ardalan Maryam M Chumak Tetyana T Svedin Pernilla P Jonsson Lina L Jabbari Shiadeh Seyedeh Marziyeh SM Goretta Fanny F Ikeda Tomoaki T Hagberg Henrik H Sandberg Mats M Mallard Carina C
ASN neuro 20230101
<h4>Summary statement</h4>Neonatal hypoxia-ischemia reduces nicotinamide adenine dinucleotide (NAD<sup>+</sup>) and SIRT6 levels in the injured hippocampus.Hippocampal high mobility group box-1 (HMGB1) release is significantly increased after neonatal hypoxia-ischemia.Nicotinamide mononucleotide (NMN) treatment normalizes hippocampal NAD<sup>+</sup> and SIRT6 levels, with significant decrease in caspase-3 activity and HMGB1 release.NMN improves early developmental behavior, as well as motor and ...[more]
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