Ferroptosis: A Promising Therapeutic Target for Neonatal Hypoxic-Ischemic Brain Injury.
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ABSTRACT:
SUBMITTER: Peeples ES
PROVIDER: S-EPMC9267109 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
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Ferroptosis: A Promising Therapeutic Target for Neonatal Hypoxic-Ischemic Brain Injury.
Peeples Eric S ES Genaro-Mattos Thiago C TC
International journal of molecular sciences 20220704 13
Ferroptosis is a type of programmed cell death caused by phospholipid peroxidation that has been implicated as a mechanism in several diseases resulting from ischemic-reperfusion injury. Most recently, ferroptosis has been identified as a possible key injury mechanism in neonatal hypoxic-ischemic brain injury (HIBI). This review summarizes the current literature regarding the different ferroptotic pathways, how they may be activated after neonatal HIBI, and which current or investigative interve ...[more]
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