Short-term exposure to ethanol induces transcriptional changes in nontumorigenic breast cells.

ABSTRACT: Breast cancer is a leading cause of cancer-related deaths in women. Many genetic and behavioral risk factors can contribute to the initiation and progression of breast cancer, one being alcohol consumption. Numerous epidemiological studies have established a positive correlation between alcohol consumption and breast cancer; however, the molecular basis for this link remains ill defined. Elucidating ethanol-induced changes to global transcriptional programming in breast cells is important to ultimately understand how alcohol and breast cancer are connected mechanistically. We investigated induced transcriptional changes in response to a short cellular exposure to moderate levels of alcohol. We treated the nontumorigenic breast cell line MCF10A and the tumorigenic breast cell lines MDA-MB-2

SUBMITTER: Miller GM 

PROVIDER: S-EPMC10549231 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature