Effectiveness and safety of direct oral anticoagulants versus warfarin in patients with atrial fibrillation and advanced kidney disease.

ABSTRACT:

Background

The effectiveness and safety of direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF) and advanced kidney disease (AKD) has not been fully established.

Objectives

To determine the effectiveness and safety related to pooled or specific DOACs to that with warfarin in patients with AF and AKD.

Methods

Patients with AF and AKD (estimated glomerular filtration rate < 30 mL/min) who received DOAC or warfarin from July 2011 to December 2020 were retrospectively identified in a medical center in Taiwan. Primary outcomes were hospitalized for stroke/systemic embolism and major bleeding. Secondary outcomes included any ischemia and any bleeding.

Results

A total of 1,011 patients were recruited, of whom 809 (80.0%) were in the DOACs group

SUBMITTER: Hsu CC 

PROVIDER: S-EPMC10550875 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature