Sulforaphane-driven reprogramming of gut microbiome and metabolome ameliorates the progression of hyperuricemia.

ABSTRACT:

Introduction

Currently, revealing how to prevent and control hyperuricemia has become an essential public health issue. Sulforaphane hasawiderangeofapplications in the management of hyperuricemia.

Objective

The study objective was to verify the uric acid-lowering effects and the regulation of the gut-kidney axis mediated by sulforaphane and identify host-microbial co-metabolites in hyperuricemia.

Methods

A hyperuricemia model was established by administering feedstuffs with 4% potassium oxonate and 20% yeast. Forty male Sprague-Dawley rats were randomly divided into the normal control, hyperuricemia, allopurinol, and sulforaphane groups. Animals were treated by oral gavage for six consecutive weeks, and then phenotypic parameters, metabolomic profiling, and metagenomi

SUBMITTER: Wang R 

PROVIDER: S-EPMC10555773 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature