Live and pasteurized Akkermansia muciniphila decrease susceptibility to Salmonella Typhimurium infection in mice.

ABSTRACT:

Introduction

The gut microbiome is vital for providing resistance against colonized pathogenicbacteria. Recently, specific commensal species have become recognized as important mediators of host defense against microbial infection by a variety of mechanisms.

Objectives

To examine the contribution of live and pasteurized A. muciniphila to defend against the intestinal pathogen Salmonella Typhimurium in a streptomycin-treated mouse model of infection.

Methods

C57B6J mice were pretreated with phosphate-buffered saline (PBS), live Akkermansia muciniphila (AKK), and pasteurized A. muciniphila (pAKK) for two weeks, then mice were infected by S. Typhimurium SL 1344. 16S rRNA-based gut microbiota analysis was performed before and after infection. Bacterial counts in feces and

SUBMITTER: Liu J 

PROVIDER: S-EPMC10555781 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature