The retrograde IFT dynein is required for normal function of diverse mechanosensory cilia in Drosophila.

ABSTRACT:

Introduction

Cilia biogenesis relies on intraflagellar transport (IFT), a conserved transport mechanism which functions bi-directionally to bring protein complexes to the growing ciliary tip and recycle signaling and transport proteins between the cilium and cell body. In Drosophila, anterograde IFT is critical for assembly of sensory cilia in the neurons of both chordotonal (ch) organs, which have relatively long ciliary axonemes, and external sensory (es) organs, which have short axonemal segments with microtubules in distal sensory segments forming non-axonemal bundles. We previously isolated the beethoven (btv) mutant in a mutagenesis screen for auditory mutants. Although many btv mutant flies are deaf, some retain a small residual auditory function

SUBMITTER: Sharma Y 

PROVIDER: S-EPMC10556659 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature