Toward an understanding of glucose metabolism in radial glial biology and brain development.

ABSTRACT: Decades of research have sought to determine the intrinsic and extrinsic mechanisms underpinning the regulation of neural progenitor maintenance and differentiation. A series of precise temporal transitions within progenitor cell populations generates all the appropriate neural cell types while maintaining a pool of self-renewing progenitors throughout embryogenesis. Recent technological advances have enabled us to gain new insights at the single-cell level, revealing an interplay between metabolic state and developmental progression that impacts the timing of proliferation and neurogenesis. This can have long-term consequences for the developing brain's neuronal specification, maturation state, and organization. Furthermore, these studies have highlighted the need to reassess the instruct

SUBMITTER: Andrews MG 

PROVIDER: S-EPMC10556723 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature