Epigenetic Profiles of Triple-Negative Breast Cancers of African American and White Females.

ABSTRACT:

Importance

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and appears to have disproportionately higher incidence and worse outcomes among younger African American females.

Objective

To investigate whether epigenetic differences exist in TNBCs of younger African American females that may explain clinical disparities seen in this patient group.

Design, setting, and participants

This cross-sectional study used clinical, demographic, DNA methylation (HumanMethylation450; Illumina), and gene expression (RNA sequencing) data for US patient populations from publicly available data repositories (The Cancer Genome Atlas [TCGA], 2006-2012, and Gene Expression Omnibus [GEO], 2004-2013) accessed on April 13, 2021. White and African American fem

SUBMITTER: Ensenyat-Mendez M 

PROVIDER: S-EPMC10556970 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature