Project description:Exercise induces the release of extracellular vesicles (EVs) into the circulation, which transmit signals between organs. EVs contain microRNAs (miRNAs) that inhibit mRNA translation or enhance mRNA degradation. However, the effects of exercise-induced EVs on anxiety remain poorly understood. We used microarrays to figure out the global alteration of gene expression in the hippocampus underlying stress and sedentary or exercise-induced EVs.
Project description:Local heart irradiation of 2, 8 or 16 Gy to ApoE-/- mice and follow up tp 20 and 40 weeks. Th goal of this study is to understand microvascular alterations of radiation-induced cardiactoxicity.