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Pyridazine N-Oxides as Photoactivatable Surrogates for Reactive Oxygen Species.

ABSTRACT: A method for the photoinduced evolution of atomic oxygen from pyridazine N-oxides was developed. This underexplored oxygen allotrope mediates arene C-H oxidation within complex, polyfunctional molecules. A water-soluble pyridazine N-oxide was also developed and shown to promote photoinduced DNA cleavage in aqueous solution. Taken together, these studies highlight the utility of pyridazine N-oxides as photoactivatable O(³P) precursors for applications in organic synthesis and chemical biology.

SUBMITTER: Basistyi VS

PROVIDER: S-EPMC10559729 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Pyridazine N-Oxides as Photoactivatable Surrogates for Reactive Oxygen Species.

Basistyi Vitalii S VS Frederich James H JH

Organic letters 20220309 10

A method for the photoinduced evolution of atomic oxygen from pyridazine N-oxides was developed. This underexplored oxygen allotrope mediates arene C-H oxidation within complex, polyfunctional molecules. A water-soluble pyridazine N-oxide was also developed and shown to promote photoinduced DNA cleavage in aqueous solution. Taken together, these studies highlight the utility of pyridazine N-oxides as photoactivatable O(3P) precursors for applications in organic sy ...[more]

PMID: 35262355

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