EXPANSION: a webserver to explore the functional consequences of protein-coding alternative splice variants in cancer genomics.

ABSTRACT:

Summary

EXPANSION (https://expansion.bioinfolab.sns.it/) is an integrated web-server to explore the functional consequences of protein-coding alternative splice variants. We combined information from Differentially Expressed (DE) protein-coding transcripts from cancer genomics, together with domain architecture, protein interaction network, and gene enrichment analysis to provide an easy-to-interpret view of the effects of protein-coding splice variants. We retrieved all the protein-coding Ensembl transcripts and mapped Interpro domains and post-translational modifications on canonical sequences to identify functionally relevant splicing events. We also retrieved isoform-specific protein-protein interactions and binding regions from IntAct to uncover isoform-specific functions via

SUBMITTER: Arora C 

PROVIDER: S-EPMC10560094 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature