A memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration.

ABSTRACT: The transport and accumulation of orally administered functional food-derived peptides in the brain was not fully explored. Thus, in the present study, we aimed to provide critical evidence regarding brain accumulation of a memory-improving soy dipeptide, Tyr-Pro, following oral administration. Stable isotope-labeled Tyr-Pro (Tyr-[¹³C₅,¹⁵N]Pro) was orally administered to male ICR mice at 10 or 100 mg/kg. Surprisingly, the intact labeled Tyr-Pro exhibited maximal plasma and brain levels 15 min after administration (plasma: area under the curve [AUC_0-120 min], 1331 ± 267 pmol·min/mL-plasma; brain: AUC_0-120 min of 0.34 ± 0.11 pmol·min/mg-dry brain, at 10 mg/kg). In addition, we detected labeled Tyr-Pro in the brain parenchyma, indicating

SUBMITTER: Cheng L 

PROVIDER: S-EPMC10560274 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature