Plasma proteoglycan 4: a novel biomarker for acute lung injury after pediatric cardiac surgery.

ABSTRACT:

Background

Identification of biological molecules related to post cardiopulmonary bypass (CPB) lung injury could help diagnose, predict and potentially impact patient's clinical course after cardiac surgery. Proteoglycan 4 (PRG4) initially identified as potential biomarker for patients with prolonged mechanical ventilation following CPB in a prior study. To further validate these findings, we sought to understand the association of lower plasma PRG4 with prolonged mechanical ventilation and worse lung compliance in a larger cohort of pediatric patients post CPB.

Methods

Retrospective chart review study. Pediatric Cardiac Intensive Care Unit, Tertiary Hospital. Infants <1 year old with tetralogy of Fallot, ventricular septal defect, or atrioventricular septal defect who under

SUBMITTER: Asfari A 

PROVIDER: S-EPMC10560364 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature