Association between anti-endothelial antigen antibodies and allograft rejection in kidney transplantation.

ABSTRACT:

Background

Endothelial cells are vital in the transplant immune system as semiprofessional antigen-presenting cells. Few studies have investigated the importance of anti-endothelin subtype A receptor (ETAR) antibodies in kidney transplantation. Here, we aimed to analyze the association between anti-angiotensin II type I receptor (AT1R) and anti-ETAR antibodies and the association between the presence of anti-endothelial antibodies and the risk of allograft rejection in kidney transplantation.

Methods

In total, 252 patients who underwent kidney transplantation were enrolled in this study. Antibodies for human leukocyte antigens (HLAs) and non-HLAs were analyzed immediately before transplantation. Patients were categorized based on the occurrence of antibody-mediated rejection

SUBMITTER: Lee HJ 

PROVIDER: S-EPMC10561590 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature